Physician-Formulated · Clinically Calibrated
CRYSTL
The Oral Crystalloid
Na⁺ 75 mEq/L
K⁺ 20 mEq/L
Glucose 75 mmol/L
245 mOsm/L
by Synergy MD
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CRYSTL IS AN
ORAL CRYSTALLOID.
Why The Formula Differs From IV

IV saline goes
into a vein.
CRYSTL goes
through a gut.

Standard IV saline contains 154 mEq/L sodium — correct for a vein, where it bypasses the gut entirely. An oral crystalloid faces a different challenge. It must navigate intestinal epithelium and activate cotransport mechanisms that no IV line ever touches.

The precision formula for oral delivery is 75 mEq/L sodium — the concentration validated in peer-reviewed trials as the threshold where oral rehydration matches the speed and efficacy of intravenous fluid replacement.[1,6] This is not a diluted version of the clinical formula. It is a more sophisticated one — engineered for how the body actually absorbs.

NaCl still forms its perfect cubic crystal lattice in every CRYSTL formula. The chemistry is unchanged. The concentration was calibrated for the route.

CRYSTL Oral Crystalloid Formula
245 mOsm/L
Na⁺
75 mEq/L
Sodium
Primary electrolyte.
SGLT1 cotransport driver.
K⁺
20 mEq/L
Potassium
Intracellular balance.
Muscle & nerve function.
Cl⁻
65 mEq/L
Chloride
Charge balance.
Fluid distribution.
C₆H₁₂O₆
75 mmol/L
Glucose
SGLT1 key · 1:1 Na ratio.
Active cotransport trigger.
Na⁺ : Glucose = 1:1 molar ratio · Precision-matched for SGLT1 cotransport[2,3]
245 mOsm/L · Hypotonic by design · Absorption begins immediately[1]
Clinically validated in adults · All causes of dehydration[6]
Three Expressions

Same oral crystalloid formula beneath every flavor. The electrolytes don't change. Only the experience of taking them does.

01 / 03
Blood Orange
Bitter · Bright · Citrus
Citrus Bioflavonoids Anthocyanins Vitamin C
Anthocyanins from blood orange demonstrate endothelial protection in clinical literature. Paired with the oral crystalloid base.
02 / 03
Yuzu Citrus
Floral · Tart · Aromatic
Hesperidin Nobiletin Potassium
Yuzu hesperidin shown to reduce inflammatory markers. Nobiletin supports metabolic function — relevant to our obesity medicine patient base.
03 / 03
Hibiscus
Tart · Floral · Deep
ACE Inhibition Polyphenols Antioxidants
Hibiscus sabdariffa has RCT-level evidence for mild antihypertensive effect via ACE inhibition. The most medicinal flavor we carry. Intentionally.
Clinical Mechanism

Three reasons the oral crystalloid outperforms everything else.

01
Hypotonic by Design
At 245 mOsm/L, CRYSTL sits below blood plasma concentration. Absorption begins immediately without the osmotic dilution step that hypertonic sports drinks require. Meta-analysis of 14 RCTs showed this formulation reduces IV requirement, stool output, and vomiting versus all prior formulations.[1]
245 mOsm/L · Below plasma (280–295) · No dilution step required
14 RCT meta-analysis · Reduced IV need · Faster recovery[1]
02
SGLT1 Cotransport
Sodium and glucose at a 1:1 molar ratio unlock the SGLT1 intestinal transporter — pulling ~210 water molecules per cycle across the epithelium via active transport. JAMA 2006 confirmed this mechanism is as effective as IV rehydration in adults with mild to moderate dehydration.[6]
Na⁺ : Glucose = 1:1 molar · SGLT1 activation required[2,3]
Alam NH et al. JAMA. 2006 · As effective as IV in adults[6]
03
Complete Electrolyte Profile
CRYSTL adds potassium at 20 mEq/L — completing the crystalloid profile. Potassium restores intracellular fluid balance that sodium alone cannot address, prevents exercise-associated hypokalemia, and supports cardiac and muscle function throughout recovery.
K⁺ 20 mEq/L · Intracellular repletion · Cardiac support
Na⁺ 75 + K⁺ 20 + Cl⁻ 65 · Full crystalloid electrolyte profile
Clinical References
1
Shane AL, Mody RK, Crump JA, et al. Clinical Infectious Diseases. 2017;65(12):e45–e80. IDSA Clinical Practice Guidelines. Strong recommendation, first-line ORS therapy, all age groups, all causes.
2
Flynn TG, Olortegui MP, Kosek MN. Viral Gastroenteritis. Lancet. 2024. Na⁺/glucose 1:1 molar ratio required for SGLT1 cotransport efficiency.
3
Thapar N, Sanderson IR. Lancet. 2004. Sodium-glucose cotransport mechanism and reduced osmolarity ORS design rationale.
4
Buccigrossi V et al. Potency of ORS in Inducing Fluid Absorption Is Related to Glucose Concentration. Scientific Reports. 2020. Optimal glucose 80–111 mmol/L · ESPGHAN most potent proabsorptive effect.
5
Farthing MJ. History and Rationale of Oral Rehydration. Drugs. 1987. 50–60 mmol/L Na⁺ + 90–100 mmol/L glucose = maximal water absorption in perfusion studies.
6
Alam NH, Yunus M, Faruque AS, et al. JAMA. 2006. 75 mmol/L Na⁺ / 75 mmol/L glucose ORS as effective as standard IV ORS in adults with dehydration.
Early Access

The oral
crystalloid.
Finally.

CRYSTL launches through Synergy Weight Loss & Primary Care. Patients and practitioners first.

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